Monoacylglycerol (MAGL) Lipase is a type of protein that can be found in human. While for MAGL enzyme inhibitors, most of them produce cannabinoidbehavioral effects. Similarly to many substances on Earth, menhave been trying to recreate them synthetically. MAGL Inhibitor, especially, now has its synthetic version such as KML-29. KML-29 has CAS number 1380424-42-9. It is a MAGL inhibitor that has been tested and noted to be more efficient compared to AEA in fatty acid amide hydrolase (FAAH). The one who does the KML-29 test is AASRAW, a biochemical technology company. Founded in 2008 by the experts on the field, the client can expect good quality product from those who know what they are doing. Additionally, it has been their vision to create high-quality medicine that can be purchased by anyone at an affordable price. In AASRAW’s test on KML-29, their researchers did it in murine inflammatory, sciatic nerve injury pain models, and diclofenac-induced gastric hemorrhage models. The result was very satisfactory as KML-29 was proven to be able to act as a highly selective MAGL inhibitor, reducing inflammatory and neuropathic behavior without the occurrence of cannabimimetic side effects. For KML-29 to produce such effects, it works by attenuating carrageenan-induced paw edema and completely reverses carrageenan-induced mechanical allodynia. Repeated administration of high-dose KML-29 gives tolerance to those effects. Not only that, it also can increase 2-AG levels and concomitantly reduced the arachidonic acid level. All the while, it doesn’t elevate anandamide (AEA) levels in the whole brain. When KML-29 is administrated together with CB1 and CB2, it’sable to reverse allodynia in the sciatic nerve injury model and completely prevent diclofenac-induced gastric hemorrhages. Interestingly, different to many MAGL inhibitors, KML-29 does not elicit cannabimimetic effects. And thus, it is concluded that KML-29 is a very efficient MAGL Inhibitors. KML-29 as a lone substance can be quite dangerous. It is not hazardous but should be handled with care. For those who want to make a purchase of KML-29, either for another research or as an ingredient, should be careful in purchasing the package. You will not want them to spill and injure anyone during the delivery. At AASRAW, KML-29 with purity no less than 98 percent is tightly packed and stored at -20℃, ensuring them in the best condition and keeping them safe. Order and delivery at AASRAW can only be met at 10gr at the minimum. The products will be shipped 12 hours after payment unless they exceed 1kg. In order that exceeds 1kg, it will take 3 working days after payment to be delivered. For more inquiry about AASRAW and their products, visit www.aasraw.con. CSR will be there to help you.
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